Scorpion venom demonstrated to induce apoptosis in less sensitive tumor cells (Hela) as evidenced by chromatin condensation, over expression of p53 and bax mRNA, down expression of bcl-2 mRNA and increase of activated caspases 3, 8, 9. There was no effect on either normal or hematopoietic tumor cells. Only the epithelial cancer cells showed significant cell viability reduction, with medium cytotoxic concentration (IC50) ranging from 0.6-1mgml, in a concentration-dependent manner. However, there is little scientific evidence about its potential in cancer therapy.Īdditionally, the effect of venom on tumor cell death was assayed by Fluorescence microscopy, RT-PCR and western blot. There w as no effect on either normal or hematopoietic tumor cells. Scorpion Xt 10 Ml Pdf Content Available.
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